The Hollow Man

Who is Cole Phelps?

Oh, I can recount the dry facts easily enough: lousy Marine officer who got a Silver Star anyway, good case man for the LAPD, affair with a German junkie, etc. What I'm curious about is the emotional life of the fellow. I spent upwards of twenty hours plodding around a sterile version of L.A. with the guy and I still don't have a clue. He's a lump, as unreadable and impenetrable as a copy of Kant's Kritik der reinen Vernunft written in cuneiform on a lead brick. And we can't even blame it on lousy animation. L.A. Noire's problem is, instead, structural. It exists at the unhappiest place along the spectrum from movie to game, where the developers don't do enough to create characters, and fail to give the players any tools to do it themselves.

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Alternative side-chain structures from methyl CPMG

As I have mentioned before on this blog, the use of tools like CS-ROSETTA holds the promise of determining protein structures using only the chemical shifts of its backbone atoms. In addition to potentially making NOEs and RDCs redundant, this technology allows biologists to determine the conformations of minor members of the structural ensemble, which are very difficult to obtain using conventional approaches in population-dominated techniques like NMR and X-ray crystallography. There are two limitations here, however. First, we only gain insight into the backbone, and as we know, the positions of side chains in minor states can be critical for function. In addition, backbone chemical shifts are not always available due to relaxation problems. Both weaknesses could, in principle, be addressed by extracting conformational information from the chemical shifts of methyl groups, which report on side-chain behavior and continue to give good signal even in very large proteins. This is the rationale behind a series of recent papers from the Kay lab [1-3] intended to determine changes in side-chain rotameric state from methyl relaxation-dispersion data.

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What Blackwater should do

Fundamentally, the bodyguards' mission differed from that of the U.S. military, noted Hammes. "The contractor was hired to protect the principal. He had no stake in pacifying the country. Therefore, they often ran Iraqis off the roads, reconned by fire, and generally treated locals as expendable." Yet Iraqis saw them as acting under American authority. "You have loosed an unaccountable, deadly force into their society, and they have no recourse."

— Thomas Ricks, Fiasco

The annual Electronic Entertainment Expo continues, producing a deluge of coverage and critique as journalists and bloggers debate the merits of this hotly-anticipated sequel and that oddly-named, overpriced new platform. All the games get some coverage, but many sink beneath the tide of information. The announcement by Backbreaker publisher 505 Games' upcoming "FPX" Blackwater seems to be one such. For those who recall the outrage that greeted the announcement of Atomic Games' still-unreleased Six Days in Fallujah this might come as a surprise. Blackwater Worldwide (now renamed Xe) was one of the most infamous of the private military contractors employed in Iraq, involved in several incidents that remain a sore point with Iraqis, and has been accused of violating both federal and international law. Yet the mainstream press, which frothed at the mouth at the thought of a legitimate attempt to portray the struggles of actual U.S. soldiers, seems content to let slide a game where you play as a mercenary in an organization that has murdered civilians and smuggled weapons, doing real harm to U.S. interests in the process. 505 Games does not owe the world a game that criticizes Blackwater, but it should produce a game that engages criticisms of the organization in a more-than-superficial way.

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Identity Crysis

Let me start by stating something important, which is that Crysis 2 is an excellent game and worth playing if you have ever enjoyed first-person shooters at all. The core design is very strong, especially the extent to which the nanosuit was tuned to make the player feel like a badass without feeling invulnerable. On many levels, however, I thought the game couldn't really decide what it wanted to be about. Is it a game about making sound tactical choices in an operation against a superior force, or is it a (bad) story about squid attacking New York City with a bioweapon?

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Capsule: Might & Magic: Clash of Heroes HD

Status: Story complete, no attempt at multiplayer

Put this on your (virtual) box: Match three for triumph!

Most intriguing idea: Making a puzzle-strategy-RPG.

Best design decision: Using troop distributions on the battlefield as a substrate for the puzzle

Worst design decision: Inadequately balancing the initial grid states.

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A few thoughts on Portal 2

While I still have it fresh in my mind I want to put down my thoughts about the single-player campaign in Portal 2. I haven't played any of the co-op, primarily because of the mysterious, ongoing problem with the PSN. However, I completed the solo campaign, and while I agree with many of the criticisms Michael Barnes made in his review at No High Scores, I greatly enjoyed Portal 2. I don't think it's a 10/10 masterpiece, but it is a very good game.

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Capsule: Beyond Good & Evil HD

Status: Complete, achievements 100%

Put this on your (virtual) box: The image is mightier than the stick!

Most Intriguing Idea: That years of word-of-mouth would produce a strong market for an up-rezzed version of a largely ignored game

Best Design Decision: Making the protest signs more legible

Worst Design Decision: The camera behavior, especially in the Slaughterhouse area


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The classic Alzheimer's aggregates are linked

The classic neuropathological hallmarks of Alzheimer's disease are the appearance of amyloid plaques composed primarily of amyloid beta (Aβ) peptides, and neurofibrillary tangles composed mainly of hyperphosphorylated tau protein. For many years, research into treatments for Alzheimer's disease proceeded on the hypothesis that the plaques were toxic to the surrounding neurons. More recently, however, evidence has shown that soluble Aβ oligomers may be the primary toxic species. A recent paper in Proceedings of the National Academy of Sciences supports this hypothesis by showing that Aβ oligomers isolated from the brains of Alzheimer's sufferers cause neuronal degradation and improper phosphorylation of tau (1). This paper is open access, so open it up and read along.

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The trouble with Tripitaka

During the "Females on Female Characters" panel at PAX, Susan Arendt argued briefly in support of Tripitaka (Trip), a character from Enslaved: Odyssey to the West. This appreciation seemed bizarre to me, so the moment stuck in my mind. Enslaved was a gorgeous game with phenomenal voice acting, decently expressive gameplay, and very bad writing, of which I thought Trip was a prime example. The game apparently wants us to like and sympathize with Trip, but she struck me as a perfectly reprehensible person in general, and seemed to represent patriarchal stereotypes more than she undermined them.

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Two (too?) easy games

The most difficult part of reviewing a game is reviewing the difficulty. A few games — Super Meat Boy, I Wanna be the Guy — can uncontroversially be called hard, but the essential question is actually whether they are too hard. Since that level of difficulty depends not only on the individual player's skills and experience, but also on his values, it can be difficult to state what goes over the line. It is even harder to accurately say whether a game is too easy, primarily because most reviewers are skilled and experienced gamers, many of them drawn to the hobby during its early days when challenge was practically all a game could offer in terms of fun. "Too easy" often equates to boring, perhaps to the detriment of games like Soul Bubbles. I have seen the "too easy" charge leveled at two games I played recently, Kirby's Epic Yarn and de Blob 2. In both cases, the statement is wrong, but for very different reasons.

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PAX East 2011 Roundup

I spent the weekend at PAX East, checking out upcoming games and meeting great people. That last one was a bit more difficult thanks to the enormous size of the BCEC, but that size made panels much easier to get into and allowed for an expanded and much nicer exposition floor. In case you weren't there, here are some impressions...

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Arcology

When I was a boy my family used to joke that crows didn't fly in Vestavia. Our suburb, like so many others, had a knotty system of streets that made direct travel impossible, and zoning that made driving a necessity. My high school was less than 2/3 of a mile direct distance from my house, but it was a two-mile drive down a road that became pretty backed up around 7:45 AM. Of course nobody rode the bus. Suburban living allowed my brother and I to go to a good school, live in a big house, and play in the woods frequently as we grew up. It also used a lot of gas.

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